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Postdocoral Associate - Web-based Bioinformatics Visualization and Data Analysis Development
- Main Laboratory Skills:
- object-oriented programming
- SQL database access and design
- data visualization and GUI development
- The University of Kentucky’s Metabolomics Center supported by NIH Common Funds seeks a Postdoctoral Scientist in Web-based Bioinformatics Visualization and Data Analysis Development. The Center (http://rcsirm.cesb.uky.edu) is an internationally renowned, high-technology, national core resource that serves the metabolomics needs of researchers, with a focus on stable isotope-resolved metabolomics (SIRM). In addition to serving the at-large scientific community, the Directors of the Center conduct federally-funded, highly translational, metabolism-based research. Candidates should have a multidisciplinary background, preferably with complementary degrees across both biological and computational disciplines such as mathematics, computer science, informatics, statistics, physiology, biochemistry, molecular or cell biology; at least one degree must be at the Ph.D. level. Candidates must have strong programming skills in at least one of the following languages: C++, Java, Python, and/or R, preferably within a Unix/Linux environment. Candidates should have experience with developing and directly accessing/using databases in one of the following database platforms: MySQL, PostgreSQL, SQLite, DB2, or Oracle. Also, experience with Apache web servers, QEMU/KVM Linux virtual machines, Git version control tools, the Galaxy platform, and Cytoscape is desirable. The position provides the opportunity to work with a team developing a web-based metabolomics data analysis and omics-integration pipeline that is actively used in the Center. Development of new informatics and visualization tools is also a responsibility of the position. Salary and benefits are competitive and commensurate with experience. Please send inquiries, curriculum vitae, and contact information for three references to: Dr. Hunter Moseley, firstname.lastname@example.org. You may be subsequently contacted to complete a formal application on-line. The University of Kentucky is committed to a policy of providing equal employment opportunities to all candidates regardless of economic or social status and will not discriminate on the basis of race, color, ethnic origin, national origin, creed, religion, political belief, sex, sexual orientation, marital status, or age. For more information, please see http://www.uky.edu/HR/working/ .
Postdoctoral Associate - Biochemist
The University of Kentucky’s Center for Environmental and System Biochemistry (CESB) is seeking a full-time Research Associate to interface with investigators of the nation’s newest NCI-designated cancer center, the Markey Cancer Center (MCC), to assist in experimental design, schedule provision of samples and analyses, conduct analyses and data analysis, and manage any other logistics of the analytical pipeline for these investigators. The incumbent will be the principal contact for MCC investigators utilizing the metabolomics resources of MCC, and will liaise with the analytical instrument managers, operators, and PIs of the CESB.. Details of duties will depend on the candidate’s background as well as skill set developed under training proved by the CESB, but will include: (i) preparing and submitting samples to the appropriate analytical platforms, which are principally mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR) (ii) Submit and/or conduct the metabolite analyses as well as majority of the data analysis which consists of metabolite identification and quantification, as well as isotopologue and isotopomer distribution analysis, normalization, and basic flux analyses. (iii) Conduct QC/QA of analyses to determine whether samples, sample preparation, and any other aspect of analysis are adequate and carry out corrective actions if analyses are inadequeate. (iv) Assist in training of personnel on metabolomic experiments and analysis as directed. (v) Maintain accurate and detailed records of samples analyzed. (vi) Prepare reports of results of samples analyzed, including preparing data sharing uploads to NIH data repositories as required. (vii) Conduct billing and prepare invoices for sample analysis as necessary. (viii) Interact with CESB personnel, PIs, and MCC investigators to resolve any issues, as necessary. (ix) Assist any MCC faculty with writing proposals and papers based on studies to be performed and samples analyzed. An extremely high value is placed on accountability and timely followthrough of the duties.
Postdoctoral Associate - Mass Spectrometrist-ICPMS
- Main Laboratory Skills:
The Center for Environmental and Systems Biochemistry (CESB) (http://bioinformatics.cesb.uky.edu/bin/view/RCSIRM/AboutUs), University of Kentucky is recruiting a postdoctoral scholar with ICP-MS expertise to start immediately. The incumbent is expected to conduct NIEHS-funded research on speciation of organometalic (especially arseno and seleno) compounds and proteins present in mammalian cell cultures, animal and human tissues using IC-ICP-MS, as well as element imaging of tissues by employing laser ablation coupled to ICP-MS. CESB houses a state-of-the-art Agilent 8800 ICP-QQQ, coupled to a Dionex ion chromatography LC ICS-5000 and a laser ablation unit to be purchased this Fall. In addition, CESB is well endowed for organic mass spectrometry including two Thermo Orbitrap Fusion Tribrid and a Bruker SolariX XR mass spectrometers capable of ultra high mass resolution. Together with high-field automated NMR spectrometers (recently installed 14.1 T, to be installed 16.5 T) and an MRI/MRS system (9.4 T capable of microimaging and spectroscopy), CESB develops and conducts cutting-edge stable isotope-resolved metabolomic (SIRM) research to gain mechanistic understanding of human diseases with a focus on cancer. CESB maintains a multi-disciplinary research environment enabling diverse collaborations involving metabolic biochemistry, cell and molecular biology, biophysics, analytical chemistry, histopathology, bioinformatics, and clinical translational sciences. Salary will commensurate with experience. Please contact Drs. Teresa Fan ( email@example.com) or Richard Higashi ( firstname.lastname@example.org) for application and further information.
As a postdoctoral scholar, you are eligible for University health benefits and you will be entitled to fifteen (15) working days of vacation in addition to the holidays observed by the university staff. For a description of your eligibility for other University benefits, please consult the UK Administrative Regulations, AR II-4.0-1, available on the UK web site. For more information, please see http://www.uky.edu/HR/working/.
Postdoctoral Associate - NMR for stable isotope resolved metabolomics
The Center for Environmental Systems Biochemistry (CESB) has a position available for postdoctoral scholars who are interested in human cancer metabolism, using high resolution NMR and in vivo NMR/imaging technologies. Our expectations for a research scholar include contributing intellectually to the project(s), proactive initiative on the project(s), helping with staff training and achieving good productivity without strict consideration for working hours. Your responsibility will be to conduct NMR analyses of stable isotope-resolved metabolomic (SIRM) experiments on cell cultures, animal models, and human tissues with the goal of defining cancer-specific reprogrammed metabolic pathways and how they respond to environmental stresses. You are also expected to help identify a few important metabolic targets for further proof-of-concept development as therapeutic agents. You are expected to analyze isotopomer distributions NMR analysis of biological extracts and metabolic pathway reconstruction based on SIRM data, and from different mass spectrometry platforms for which training will be provided. You will also be expected to assist with routine maintenance of the NMR instrumentation and development and implementation of novel experiments.
You will be expected to contribute to the research output of the laboratory in the form of presentations at conferences as well as preparing manuscripts and proposals, and in general, assistance with the analytical load of CESB through the RCSIRM center and its collaborative projects.
CESB currently has a 14.1 T Agilent DD2 spectrometer with automation and a 3 mm HCN cold probe, a 16.45 T Bruker Avance III spectrometer with dual receiver, 1.7 mm HCN cryoprobe and a 5 mm HCNP quad cryoprobe and a Bruker 9.4 T imaging/spectrometer.
A solid background in NMR and applications is required, and a strong interest in metabolic biochemistry.
Please contact Dr. Andrew Lane (email@example.com
) or Dr. Teresa Fan (firstname.lastname@example.org
) for further information or application.
We are always looking for enthusiastic undergraduate and graduate students that want to learn cutting-edge SIRM methods and research.
Please contact us to discuss opportunities.
- We accept graduate students from the University of Kentucky's IBS Program.
- There are opportunities for undergraduates via the University of Kentucky's STEPS Program.
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