PD/PI (Center co-I) | Grant / Title | Period | Total Award ($M) |
---|---|---|---|
R.M. Higashi (Fan, Lane, Moseley) | U24 Administrative supplement-Ring Trial | 9/1/14-3/1/15 | 0.038 |
C. Wang (PD), H. Moseley (MPI) | R21 CA205778 Statistical Detection and Biochemical Classification of Cancer Driver Mutation Patterns in Biological Networks | 08/01/16-07/31/18 | 0.564 |
E. Repasky (A.N. Lane & T. W-M. Fan subcontract) | R01 CA205246 Understanding how adrenergic signaling influences immune contexture of tumors and the efficacy of checkpoint inhibitors: subcontract from RPMI/ E. Repasky | 2018-2023 | 0.45 |
K. Ghoshal (T. Fan) | NIH R01 Role of miRNA-122 in hepatocarcinogenesis using conditional knock out mice (subcontract) | 2/15-1/18 | 0.054 |
D. St. Clair (A. Lane, R. Higashi Metabolism Core Directors) | NIGMS P20GM121327 "University of Kentucky Center for Cancer and Metabolism" Metabolism Core | 3/31/17-2/28/22 | 1.02 |
J. Albrecht (Fan, Lane, Higashi) | NIDDK R01 DK054921-15 Cyclin D1/CDK4 Complex in Hepatocyte Proliferation (subcontract) | 5/1/14-4/30/16 | 0.17 |
T. W-M. Fan, A.N. Lane | NCI Targetted Opportunity Collaborative Agreement | 9/1/14-8/31/17 | 1.25 |
C. Wang, R. Flight, H. Moseley | NCI R03CA211835 -01 Differential Abundance Methods for Large Heterogeneous-Featured Metabolomics Datasets | 9/14/16-8/31/17 | 0.145 |
T. W-M. Fan (S. Arnold, J. Martin, A. Lane) | KLCRP Biomarker Discovery by Interrogating Lung Cancer Lipid Metabolome
|
7/15-6/17 | 0.15 |
T. W-M. Fan (Higashi, Moseley) | BCAL Ltd. Blood Exosomes in Breast Cancer (contract) | 1/14-6/17 | 0.63 |
A.N. Lane (PD), T. Fan, S. Arnold | Administrative supplement to 1P01CA163223-01A1 - | 1/1/16-12/31/16 | 0.072 |
T. W-M. Fan (PI) & .M. Higashi (co-I) | 2R01ES019616-06 ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure: subcontract |
2017-2021 | |
T. W-M. Fan (Higashi, Moseley, Nantz) | 1R01ES022191-01 - Integrated Chemoselective and Informatic Platform for Large-Scale Metabolomics | 10/01/12 - 06/30/17 | 2.24 |
R.M. Higashi (Fan, Lane, Moseley) | 1U24DK097215-01A1 - Resource Center for Stable Isotope-Resolved Metabolomics | 09/11/2013 - 08/31/2018 | 8.7 |
T. W-M Fan, T. Izumi, X. Shi | 1R21 ES025669-01 Mitochondrial Metabolic Reprogramming and DNA Damage in Arsenic Carcinogenesis | 6/15-5/18 | 0.413 |
S. Biswal (T. Fan subcontract) | 1R01CA206155-01 Crosstalk of LKB1 and KEAP1 mutations in driving growth of lung adenocarcinoma | 4/15/16-3/31/17 | 0.05 |
J. Liu (PD) and R. Higashi (MPI) | 1 R03 CA222449-01 Algorithms for Accurate and Scalable Identification of Isotopologues from Mass Spectrometry Data |
2018-2019 | 0.15 |
T. Barrett, UKy (A. Lane co-I) | 1 R21 DK118954-01 Peripheral Blood Exosome Lipids as Biomarkers of Disease Activity in Crohn’s Disease | 9/1/18-20 | |
R. Wang (T.. Fan, A. Lane subcontract) | 1U01CA232488-01 Metabolic reprogramming of tumor microenvironment to maximize immunotherapy for pediatric cancers | 09/17/2018 – 06/30/2023 | |
D. St. Clair (T. Fan, H. Moseley, co-Is) | 5R01 CA73599 Redox Regulation of Tumor Suppression by MnSOD | 12/18/17-11/30/22 | |
D. St. Clair (PD), T. Fan, MPI | 2T32ES007266-26A1 Training Grant in Molecular Mechanisms of Toxicity | 7/16-6/21 | |
24.62 Total | |||
A.N. Lane (Fan, Yan, Higashi, Moseley) | 1P01CA163223-01A1 - Systems Biochemistry in Lung Cancer: Toward a Mechanistic Understanding of NSCLC | 03/01/13 - 02/28/18 | 7.13 |
H.N.B.Moseley | NSF 1252893 - CAREER:Developing Biochemoinformatics Tools for Large Scale Metabolomics Applications | 07/01/13 - 06/30/18 | 1.1 |
PD/PI | Grant / Title | Period | Total Award ($M) |
---|---|---|---|
X. Fu (U. Louisville) | NSF CBET-1159829 - A Chemoselective Microreactor Device for Trace Carbonyl VOC Analysis | 08/15/12 - 07/31/15 | 0.3 |
J. Albrecht (U. Minnesota) | NIDDK R01 DK054921-15 Cyclin D1/CDK4 Complex in Hepatocyte Proliferation | 5/1/14-4/30/16 | 1.5 |
T. Gao (U. Kentucky) | NCI 2R01 CA133429-08 : The Role of PHLPP in Colon Cancer | 11/14-10/19 | 1.68 |
K. Ghoshal (Ohio State U.) | NIDDK R01 Role of miRNA-122 in hepatocarcinogenesis using conditional knock out mice | 2/15-1/20 | 1.5 |
S.R. Allie (U. Alabama) | NIH F32 Establishment and metabolic control of influenza-specific lung resident memory B cells | 6/15-6/18 | 0.165 |
F. Onono (U. Kentucky) | NCI K01CA197073 -01 "Intestinal phosphatidylcholine exposure and breast cancer risk" | 7/1/15-6/30/20 | 0.702 |
P.P. Scaglioni (UT S. Western) | CPRIT: Mutant KRAS reprograms lipid homeostasis in lung cancer establishing treatment opportunities | 2015-2017 | |
B.M. Evers (U. Kentucky) | NIDDK 5R01 DK048498-21: "Mechanistic Impact of P13K /mTOR Signaling on Intestinal Homeostasis" | 7/15-6/20 | 1.82 |
P. Hosein, R.M. Higashi (U. Kentucky) | CCSG A pilot neoadjuvant study in patients with resectable pancreatic ductal adenocarcinoma as a platform for in-vivo testing of novel therapies |
1/1/16-12/31/17 | 0.05 |
V. Ragnekar & B.M. Evers (U. Kentucky) | NIH T32 Training Grant | 5/1/16- | |
M. Chen (U. Kentucky) | KLCRP | 2016-2018 | 0.15 |
E. Hahn (U. Kentucky) | KLCRP " Radon and Tobacco Smoke Exposure Biomarkers of Lung Cancer Risk " | 2016-2018 | 0.15 |
V. Boussiotis (BIDMC) | NCI Effects of PGE2 on reconstitution of hematopoiesis and immunity in UCBT (supplement to parent grant: R01CA183605 -01) | 2016-2017 | |
D. St. Clair, UKY (Lane, Fan, Higashi co-Is) | NIGMS P20GM121327 "University of Kentucky Center for Cancer and Metabolism" | 3/2017-3/2022 | 11.12 |
Q. Wei, UKY (A. Lane Co-I) | KLCRP "Sulfiredoxin-mediated Metabolic Alterations in non small cell lung cancer " | 1/2018-12/2019 | 0.15 |
R. Xu, UKY (A. Lane co-I) | NCI 1R01CA215095-01 "Roles of RORalpha in Breast Cancer Development and Progression" | 7/17-6/22 | 1.72 |
X. Shi, UKY (T. Fan, R. Higashi co-Is) | NIEHS 1P30ES026529-01A1 Center for Appalachian Research in Environmental Sciences | 2017-2022 | 1.496 (annual) |
B. M. Evers, UKY | NIDDK R01 DK103913 Neurotensin regulation, secretion and function in health and disease | 2017-2022 | |
B. M. Evers & T. Gao, UKY (R Higashi co-I) | NCI R01 Altered Lipid Metabolism as a Novel Target for Colon Cancer Treatment | 2017-2022 | |
S. Rajagopalan (Case Western) | 2R01ES019616-06 ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure | 9/30/2017-7/31/2021 | 1.324 total |
E. Repasky (Roswell Park MI) | NCI R01CA205246 Understanding how adrenergic signaling influences immune contexture of tumors and the efficacy of checkpoint inhibitors | 2018-2023 | |
D. St. Clair (UKY) | 5R01 CA73599 Redox Regulation of Tumor Suppression by MnSOD | 12/18/17-11/30/22 | 0.424 total annual |
M. Gentry/ R. Sun, UKy (A Lane co-I) | KLCRP Contribution of EPM2A and glycogen in NCSLC metabolism and tumorigenesis | 11/17-11/19 | 0.13 total |
T. Barrett, UKy | 1 R21 DK118954-01 Peripheral Blood Exosome Lipids as Biomarkers of Disease Activity in Crohn’s Disease | 9/1/18-20 | 0.425 total |
R. Wang (Nationwide Children's, Columbus) | 1U01CA232488-01 Metabolic reprogramming of tumor microenvironment to maximize immunotherapy for pediatric cancers | 09/17/2018 – 06/30/2023 | |
B.M. Evers & N. Vanderford, UKy (T. Fan, A.Lane mentors) | R25 Appalachian Career Training in Oncology (ACTION) Program | 10/18-9/ |
Smelter A, Moseley HNB. (2018) A Python library for FAIRer access and deposition to the Metabolomics Workbench Data Repository. Metabolomics 14(5):64.
Crooks,D.R., Maio, N., Lane, A.N., Fan, T. W-M., Jarnik, M., Haller, R.G., Higashi, R.M., Yang, Y., Linehan, W.M., Rouault, T.A. A novel pathway generates lipid droplets in cells unable to synthesize iron sulfur clusters. J. Biol. Chem. 293, 8297–8311 doi: 10.1074/jbc.RA118.001885*
Zaytseva, Y.Y., Rychacho, P.G., Le, A-T., Scott, T.L., Flight, R.M., Kim, J.T., Harris, J., Liu, J., Wang, C., Morris, A., Arumugam, S.T., Fan, T.W-M., Moseley, H.N.B., Gao, T., Lee, E.Y., Weiss, H., Heuer, T.S., Kemble, G. & Evers, B.M. (2018) Activation of Akt pathway and autophagy promotes resistance to fatty acid synthase inhibition in colorectal cancer. Oncotarget 9:24787-24800
Fan, T. W-M., El-Amouri, S.S., Macedo, J.K.A., Wang, Q.J., Cassel, T.A. and Lane, A.N. (2018) Mapping Metabolic Networks in 3D Spheroids Using Stable Isotope-Resolved Metabolomics. Metabolites 8, 40
Liu, J., Murali, T., Liu, C., Yu, T., Arumugam, S.T., Moseley, H.N.B., Jouline, I., Weiss, H.L., Durbin, E., Ellingson, S., Liu, J., Hallahan, B.J., Horbinski, C., Fardo, D., Wang, C, Arnold, S.M.(2018) Characterization of Squamous Cell Lung Cancers from Appalachian Kentucky. Cancer Epidemiol. Biomarkers & Prevention. In press
Mitchell, J.M., Flight, R.M., Wang, Q., Lane, A.N., Higashi, R.M., Fan, T. W-M., and Moseley, H.N.B.. Detection and Handling of Spectral Artefacts in Fourier Transform Mass Spectra of Metabolomics Experiments. Metabolomics 14, 125
Lian, G., Gnanaprakasam, J.N.R., Wang, T., Wu, R., Chen, X., Liu, L., Shen, Y., Yang, M., Yang, J., Chen, Y., Vasiliou, V., Cassel, T.A., Green, D.R., Liu, Y., Fan, T.W.-M. & Wang, R. (2018) Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.eLife 7:e36158
Lane, A.N., Tan, J., Wang, Y., Yan, J., Higashi, R.M., Fan, T.W-M. (2017) Probing the metabolic phenotype of breast cancer cells by multiple tracer Stable Isotope Resolved Metabolomics. Metabolic Engineering sp issue 43, 125-136
Lane, A.N. & Fan, T. W-M. (2017) NMR-Based Stable Isotope Resolved Metabolomics in Systems Biochemistry. Arch. Biochem. Biophys. 628, 123-131
S Yao, RM Flight, EC Rouchka, HNB Moseley (2017) Aberrant coordination geometries discovered in the most abundant metalloproteins. Proteins: Structure, Function, and Bioinformatics. 85, 885-907
S Yao, RM Flight, EC Rouchka, HNB Moseley (2017) Perspectives and expectations in structural bioinformatics of metalloproteins. Proteins: Structure, Function, and Bioinformatics, 85, 938-944
Yang, Y., Higashi, R.M., Lane, A.N., Fan, T. W-M. (2017) Chloroformate Derivatization for Tracing the Fate of Amino Acids in Cells and Tissues by Multiple Stable Isotope Resolved Metabolomics (mSIRM). Anal. Chim. Acta 976, 63-73
Hardwick, J.S., Ptchelkine, D., El Sagheer, A.H., Tear, I., Singleton, D., Phillips, S.E.V., Lane, A.N. & Brown, T. (2017) 5-formylcytosine does not change the global structure of DNA Nat. Struct. Molec. Biol. 24, 544552
Matrka, M.C., Watanabe, M., Menon, R.M., Lambert, P.F., Lane, A.N., Romick-Rosendale, L.E., Wells, S.I. Overexpression of the human DEK oncogene reprograms cellular metabolism. PLoS One 12: e0177952
Webb, S., Nagy, T., Moseley, H.N.B., Fried, M., Dutch, R.E. (2017) "Hendra virus fusion protein transmembrane domain contributes to pre-fusion protein stability" J. Biol. Chem. 292, 5685.
Bruntz, R., Higashi, R.M., Lane, A.N., Fan, T. W-M. (2017) Exploring Cancer Metabolism using Stable Isotope Resolved Metabolomics (SIRM). J. Biol. Chem. 292, 11601-11609
Kuperman RG, Checkai RT, Simini M, Phillips CT, Higashi RM, Fan TW, Sappington K. (2017) Selenium Toxicity To Survival And Reproduction Of Collembola And Enchytraeids In A Sandy Loam Soil.Environ Toxicol Chem. 37:846-853 doi: 10.1002/etc.4017
Deng, P., Higashi, R.M., Lane, A.N., Bruntz, R.C., Sun, R.C., Raju, R.R., Nantz, M.H., Qi, Z., Fan, T. W-M. (2017) Quantification and Identification of Carbonyls Using Chemoselective Tagging and Nanospray FT-MS. Analyst. 43, 311-322
Fan, T. W-M., El-Amouri, S.S., Macedo, J.K.A. & Lane, A.N. (2017) Mapping Metabolic Networks in 3D spheroids using Stable Isotope-Resolved Metabolomics (SIRM). In Proceedings of the The 2nd International Electronic Conference on Metabolomics, 20–27 November 2017; Sciforum Electronic Conference Series, 2, 2017 ; doi:10.3390/iecm-2-05035
Fan, T. W-M. & Lane, A.N. (2016) Applications of NMR to Systems Biochemistry. Prog. NMR Spectrosc. 92,18-53
Sud M, Fahy E, Cotter D, Azam K, Vadivelu I, Burant C, Edison A, Fiehn O, Higashi R, Nair KS, Sumner S, Subramaniam S. (2016) Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools. Nucleic Acids Res. 44(D1):D463-70.
Fan, T. W-M., Warmoes, M.O., Sun, Q., Song, H., Turchan-Cholewo, J., Martin, J.T., Mahan, A.L.,Higashi, R.M., Lane, A.N. (2016) Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator beta-glucan in a two-case ex vivo non-small cell lung cancer study. CSH Molecular Case Studies J. 2, a0008.