Center Funding Support and Publications

Acknowledging the Center

You must acknowledge the Center's grant number (1U24DK097215-01A1) on any of your publications using the facility and send us an electronic copy of the published work (e.g. we thank the support of the Resource Facility for Stable Isotope Resolved Metabolomics funded by NIH grant # 1U24DK097215-01A1).

Grant Funding

Center Faculty

Summary of extramural funding for Center faculty.
  • Grants include at least 1 Center faculty as PD, PI, or co-I.
PD/PI (Center co-I) Grant / Title Period Total Award ($M)
T. W-M. Fan (Higashi, Moseley, Nantz) 1R01ES022191-01 - Integrated Chemoselective and Informatic Platform for Large-Scale Metabolomics 10/01/12 - 06/30/17 2.24
A.N. Lane (Fan, Yan, Higashi, Moseley) 1P01CA163223-01A1 - Systems Biochemistry in Lung Cancer: Toward a Mechanistic Understanding of NSCLC 03/01/13 - 02/28/18 7.13
H.N.B.Moseley NSF 1252893 - CAREER:Developing Biochemoinformatics Tools for Large Scale Metabolomics Applications 07/01/13 - 06/30/18 1.1
R.M. Higashi (Fan, Lane, Moseley) 1U24DK097215-01A1 - Resource Center for Stable Isotope-Resolved Metabolomics 09/11/2013 - 08/31/2018 8.7
T. W-M. Fan (Higashi, Moseley) BCAL Ltd. Blood Exosomes in Breast Cancer (contract) 1/14-6/17 0.63
T. W-M. Fan, A.N. Lane NCI Targetted Opportunity Collaborative Agreement 9/1/14-8/31/17 1.25
R.M. Higashi (Fan, Lane, Moseley) U24 Administrative supplement-Ring Trial 9/1/14-3/1/15 0.038
J. Albrecht (Fan, Lane, Higashi) NIDDK R01 DK054921-15 Cyclin D1/CDK4 Complex in Hepatocyte Proliferation (subcontract) 5/1/14-4/30/16 0.17
T. W-M. Fan (S. Arnold, J. Martin, A. Lane) KLCRP Biomarker Discovery by Interrogating Lung Cancer Lipid Metabolome

7/15-6/17 0.15
K. Ghoshal (T. Fan) NIH R01 Role of miRNA-122 in hepatocarcinogenesis using conditional knock out mice (subcontract) 2/15-1/18 0.054
T. W-M Fan, T. Izumi, X. Shi 1R21 ES025669-01 Mitochondrial Metabolic Reprogramming and DNA Damage in Arsenic Carcinogenesis 6/15-5/18 0.413
D. St. Clair (PD), T. Fan, MPI 2T32ES007266-26A1 Training Grant in Molecular Mechanisms of Toxicity 7/16-6/21  
C. Wang (PD), H. Moseley (MPI) R21 CA205778 Statistical Detection and Biochemical Classification of Cancer Driver Mutation Patterns in Biological Networks 08/01/16-07/31/18 0.564
S. Biswal (T. Fan subcontract) 1R01CA206155-01 Crosstalk of LKB1 and KEAP1 mutations in driving growth of lung adenocarcinoma 4/15/16-3/31/17 0.05
A.N. Lane (PD), T. Fan, S. Arnold Administrative supplement to 1P01CA163223-01A1 - 1/1/16-12/31/16 0.072
C. Wang, R. Flight, H. Moseley NCI R03CA211835 -01 “Differential Abundance Methods for Large Heterogeneous-Featured Metabolomics Datasets” 9/14/16-8/31/17 0.145
D. St. Clair (A. Lane, R. Higashi Metabolism Core Directors) NIGMS P20GM121327 "University of Kentucky Center for Cancer and Metabolism" Metabolism Core 3/31/17-2/28/22 1.02
J. Liu (PD) and R. Higashi (MPI) 1 R03 CA222449-01 “Algorithms for Accurate and Scalable Identification of Isotopologues from Mass Spectrometry Data “
2018-2019 0.15
T. W-M. Fan (PI) & .M. Higashi (co-I) 2R01ES019616-06 ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure: subcontract
E. Repasky (A.N. Lane & T. W-M. Fan subcontract) R01 CA205246 Understanding how adrenergic signaling influences immune contexture of tumors and the efficacy of checkpoint inhibitors: subcontract from RPMI/ E. Repasky 2018-2023 0.45
D. St. Clair (T. Fan, H. Moseley, co-Is) 5R01 CA73599 Redox Regulation of Tumor Suppression by MnSOD 12/18/17-11/30/22  
T. Barrett, UKy (A. Lane co-I) 1 R21 DK118954-01 Peripheral Blood Exosome Lipids as Biomarkers of Disease Activity in Crohn’s Disease 9/1/18-20  
R. Wang (T.. Fan, A. Lane subcontract) 1U01CA232488-01 Metabolic reprogramming of tumor microenvironment to maximize immunotherapy for pediatric cancers 09/17/2018 – 06/30/2023  
      24.62 Total

Center Supported

Summary of known extramural funding that is supported by the Center.
PD/PI Grant / Title Period Total Award ($M)
X. Fu (U. Louisville) NSF CBET-1159829 - A Chemoselective Microreactor Device for Trace Carbonyl VOC Analysis 08/15/12 - 07/31/15 0.3
J. Albrecht (U. Minnesota) NIDDK R01 DK054921-15 Cyclin D1/CDK4 Complex in Hepatocyte Proliferation 5/1/14-4/30/16 1.5
T. Gao (U. Kentucky) NCI 2R01 CA133429-08 : The Role of PHLPP in Colon Cancer 11/14-10/19 1.68
K. Ghoshal (Ohio State U.) NIDDK R01 Role of miRNA-122 in hepatocarcinogenesis using conditional knock out mice 2/15-1/20 1.5
S.R. Allie (U. Alabama) NIH F32 Establishment and metabolic control of influenza-specific lung resident memory B cells 6/15-6/18 0.165
F. Onono (U. Kentucky) NCI K01CA197073 -01 "Intestinal phosphatidylcholine exposure and breast cancer risk" 7/1/15-6/30/20 0.702
P.P. Scaglioni (UT S. Western) CPRIT: Mutant KRAS reprograms lipid homeostasis in lung cancer establishing treatment opportunities 2015-2017  
B.M. Evers (U. Kentucky) NIDDK 5R01 DK048498-21: "Mechanistic Impact of P13K /mTOR Signaling on Intestinal Homeostasis" 7/15-6/20 1.82
P. Hosein, R.M. Higashi (U. Kentucky) CCSG “A pilot neoadjuvant study in patients with resectable pancreatic ductal adenocarcinoma as a platform for in-vivo testing of novel therapies”
1/1/16-12/31/17 0.05
V. Ragnekar & B.M. Evers (U. Kentucky) NIH T32 Training Grant 5/1/16-  
M. Chen (U. Kentucky) KLCRP 2016-2018 0.15
E. Hahn (U. Kentucky) KLCRP " Radon and Tobacco Smoke Exposure Biomarkers of Lung Cancer Risk " 2016-2018 0.15
V. Boussiotis (BIDMC) NCI “Effects of PGE2 on reconstitution of hematopoiesis and immunity in UCBT” (supplement to parent grant: R01CA183605 -01) 2016-2017  
D. St. Clair, UKY (Lane, Fan, Higashi co-Is) NIGMS P20GM121327 "University of Kentucky Center for Cancer and Metabolism" 3/2017-3/2022 11.12
Q. Wei, UKY (A. Lane Co-I) KLCRP "Sulfiredoxin-mediated Metabolic Alterations in non small cell lung cancer " 1/2018-12/2019 0.15
R. Xu, UKY (A. Lane co-I) NCI 1R01CA215095-01 "Roles of RORalpha in Breast Cancer Development and Progression" 7/17-6/22 1.72
X. Shi, UKY (T. Fan, R. Higashi co-Is) NIEHS 1P30ES026529-01A1 Center for Appalachian Research in Environmental Sciences 2017-2022 1.496 (annual)
B. M. Evers, UKY NIDDK R01 DK103913 Neurotensin regulation, secretion and function in health and disease 2017-2022  
B. M. Evers & T. Gao, UKY (R Higashi co-I) NCI R01 Altered Lipid Metabolism as a Novel Target for Colon Cancer Treatment 2017-2022  
S. Rajagopalan (Case Western) 2R01ES019616-06 ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure 9/30/2017-7/31/2021 1.324 total
E. Repasky (Roswell Park MI) NCI R01CA205246 Understanding how adrenergic signaling influences immune contexture of tumors and the efficacy of checkpoint inhibitors 2018-2023  
D. St. Clair (UKY) 5R01 CA73599 Redox Regulation of Tumor Suppression by MnSOD 12/18/17-11/30/22 0.424 total annual
M. Gentry/ R. Sun, UKy (A Lane co-I) KLCRP Contribution of EPM2A and glycogen in NCSLC metabolism and tumorigenesis 11/17-11/19 0.13 total
T. Barrett, UKy 1 R21 DK118954-01 Peripheral Blood Exosome Lipids as Biomarkers of Disease Activity in Crohn’s Disease 9/1/18-20 0.425 total
R. Wang (Nationwide Children's, Columbus) 1U01CA232488-01 Metabolic reprogramming of tumor microenvironment to maximize immunotherapy for pediatric cancers 09/17/2018 – 06/30/2023  
B.M. Evers & N. Vanderford, UKy (T. Fan, A.Lane mentors) R25 Appalachian Career Training in Oncology (ACTION) Program 10/18-9/  

Recent News


Summary of publications (co)-authored by Center faculty.


  1. Hardwick, J., Lane, A.N., Brown, T. (2018) Epigenetic modifications of cytosine: biophysical properties, regulation and function in mammalian DNA. BioEssays 40, 1700199. DOI: 10.1002/bies.201700199
  2. Smelter A, Moseley HNB. (2018) A Python library for FAIRer access and deposition to the Metabolomics Workbench Data Repository. Metabolomics 14(5):64.

  3. Fan, T. W-M., Zhang, X., Wang, C., Yang, Y., Kang, W-Y., Higashi, R.M., Liu, J., Lane, A.N. (2018) Exosomal lipids for classifying early and late stage non-small cell lung cancer. Anal. Chim. Acta. 1037, 256-264 10.1016/j.aca.2018.02.051
  4. Crooks,D.R., Maio, N., Lane, A.N., Fan, T. W-M., Jarnik, M., Haller, R.G., Higashi, R.M., Yang, Y., Linehan, W.M., Rouault, T.A. A novel pathway generates lipid droplets in cells unable to synthesize iron sulfur clusters. J. Biol. Chem. 293, 8297–8311 doi: 10.1074/jbc.RA118.001885*

  5. Zaytseva, Y.Y., Rychacho, P.G., Le, A-T., Scott, T.L., Flight, R.M., Kim, J.T., Harris, J., Liu, J., Wang, C., Morris, A., Arumugam, S.T., Fan, T.W-M., Moseley, H.N.B., Gao, T., Lee, E.Y., Weiss, H., Heuer, T.S., Kemble, G. & Evers, B.M. (2018) Activation of Akt pathway and autophagy promotes resistance to fatty acid synthase inhibition in colorectal cancer. Oncotarget 9:24787-24800

  6. Zhang, Y., Zhang, X., Lane, A.N., Fan, T. W-M., Liu, J. (2018) TFmeta: A Machine Learning Approach to Uncover Transcription Factors Governing Metabolic Reprogramming. BCB '18 Proceedings of the 2018 ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics pp 351-359
  7. Fan, T. W-M., El-Amouri, S.S., Macedo, J.K.A., Wang, Q.J., Cassel, T.A. and Lane, A.N. (2018) Mapping Metabolic Networks in 3D Spheroids Using Stable Isotope-Resolved Metabolomics. Metabolites 8, 40

  8. Liu, J., Murali, T., Liu, C., Yu, T., Arumugam, S.T., Moseley, H.N.B., Jouline, I., Weiss, H.L., Durbin, E., Ellingson, S., Liu, J., Hallahan, B.J., Horbinski, C., Fardo, D., Wang, C, Arnold, S.M.(2018) Characterization of Squamous Cell Lung Cancers from Appalachian Kentucky. Cancer Epidemiol. Biomarkers & Prevention. In press

  9. Mitchell, J.M., Flight, R.M., Wang, Q., Lane, A.N., Higashi, R.M., Fan, T. W-M., and Moseley, H.N.B.. Detection and Handling of Spectral Artefacts in Fourier Transform Mass Spectra of Metabolomics Experiments. Metabolomics 14, 125

  10. Lian, G., Gnanaprakasam, J.N.R., Wang, T., Wu, R., Chen, X., Liu, L., Shen, Y., Yang, M., Yang, J., Chen, Y., Vasiliou, V., Cassel, T.A., Green, D.R., Liu, Y., Fan, T.W.-M. & Wang, R. (2018) Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.eLife 7:e36158

* Editor's Choice


Z. Cui, X. Wang, S. Koppermann, J. S. Thorson, C. Ducho, and S. G. Van Lanen (2018) Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471. J. Nat. Prod. 81:942-948 DOI: 10.1021/acs.jnatprod.7b01054

Fan, T. W-M., & Lane, A.N. (2018) Stable Isotope Tracing in Cancer Metabolism CIL applications

2017 (17)

  • Lane, A.N., Tan, J., Wang, Y., Yan, J., Higashi, R.M., Fan, T.W-M. (2017) Probing the metabolic phenotype of breast cancer cells by multiple tracer Stable Isotope Resolved Metabolomics. Metabolic Engineering sp issue 43, 125-136

  • Lane, A.N. & Fan, T. W-M. (2017) NMR-Based Stable Isotope Resolved Metabolomics in Systems Biochemistry. Arch. Biochem. Biophys. 628, 123-131

  • S Yao, RM Flight, EC Rouchka, HNB Moseley (2017) Aberrant coordination geometries discovered in the most abundant metalloproteins. Proteins: Structure, Function, and Bioinformatics. 85, 885-907

  • S Yao, RM Flight, EC Rouchka, HNB Moseley (2017) Perspectives and expectations in structural bioinformatics of metalloproteins. Proteins: Structure, Function, and Bioinformatics, 85, 938-944

  • Yang, Y., Higashi, R.M., Lane, A.N., Fan, T. W-M. (2017) Chloroformate Derivatization for Tracing the Fate of Amino Acids in Cells and Tissues by Multiple Stable Isotope Resolved Metabolomics (mSIRM). Anal. Chim. Acta 976, 63-73

  • Hardwick, J.S., Ptchelkine, D., El Sagheer, A.H., Tear, I., Singleton, D., Phillips, S.E.V., Lane, A.N. & Brown, T. (2017) 5-formylcytosine does not change the global structure of DNA Nat. Struct. Molec. Biol. 24, 544–552

  • Matrka, M.C., Watanabe, M., Menon, R.M., Lambert, P.F., Lane, A.N., Romick-Rosendale, L.E., Wells, S.I. Overexpression of the human DEK oncogene reprograms cellular metabolism. PLoS One 12: e0177952

  • Webb, S., Nagy, T., Moseley, H.N.B., Fried, M., Dutch, R.E. (2017) "Hendra virus fusion protein transmembrane domain contributes to pre-fusion protein stability" J. Biol. Chem. 292, 5685.

  • Bruntz, R., Higashi, R.M., Lane, A.N., Fan, T. W-M. (2017) Exploring Cancer Metabolism using Stable Isotope Resolved Metabolomics (SIRM). J. Biol. Chem. 292, 11601-11609

  • Zhao J., Li, J., Fan, T. W-M. & Hou, S. (2017) Glycolytic Reprogramming through PCK2 Regulates Tumor Initiation of Prostate Cancer Cells Oncotarget 8, 83602-83618
  • Smelter, A., Rouchka, E.C., and Moseley, H.N.B. (2017) Detecting and accounting for multiple sources of positional variance in peak list registration analysis and spin system grouping J. Biomol. NMR 68, 281-296
  • Verdegem, D., Moseley, H.N.B., Vermaelen, W., Sanchez, A.A., and Ghesquière, B. (2017) MAIMS: A software tool for sensitive metabolic tracer analysis through the deconvolution of 13C mass isotopologue profiles of large composite metabolites. Metabolomics 13: 123
  • Sun, R.C., Fan, T. W-M., Deng, P., Higashi, R.M., Lane, A.N., Scott, T.L., Sun, Q., Warmoes, M.O., Yang, Y.(2017) Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing. Nat. Commun. 8, 1646
  • Kuperman RG, Checkai RT, Simini M, Phillips CT, Higashi RM, Fan TW, Sappington K. (2017) Selenium Toxicity To Survival And Reproduction Of Collembola And Enchytraeids In A Sandy Loam Soil.Environ Toxicol Chem. 37:846-853 doi: 10.1002/etc.4017

  • Deng, P., Higashi, R.M., Lane, A.N., Bruntz, R.C., Sun, R.C., Raju, R.R., Nantz, M.H., Qi, Z., Fan, T. W-M. (2017) Quantification and Identification of Carbonyls Using Chemoselective Tagging and Nanospray FT-MS. Analyst. 43, 311-322

  • Fan, T. W-M., El-Amouri, S.S., Macedo, J.K.A. & Lane, A.N. (2017) Mapping Metabolic Networks in 3D spheroids using Stable Isotope-Resolved Metabolomics (SIRM). In Proceedings of the The 2nd International Electronic Conference on Metabolomics, 20–27 November 2017; Sciforum Electronic Conference Series, 2, 2017 ; doi:10.3390/iecm-2-05035

  • Yang, Y. (2017) Metabolic Reprogramming of Human Lung Cancer Cells and Ex vivo Tissues Revealed by UHR-FTMS Analysis of Small Amino and Carboxyl Metabolites. PhD Thesis, University of Kentucky.

2016 (9)

  • Fan, T. W-M.,Lane, A.N., Higashi, R.M. (2016) Stable Isotope Resolved Metabolomics studies in ex vivo tissue slices. Bio-protocol 6, e1730
  • Fan, T. W-M. & Lane, A.N. (2016) Applications of NMR to Systems Biochemistry. Prog. NMR Spectrosc. 92,18-53

  • Sud M, Fahy E, Cotter D, Azam K, Vadivelu I, Burant C, Edison A, Fiehn O, Higashi R, Nair KS, Sumner S, Subramaniam S. (2016) Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools. Nucleic Acids Res. 44(D1):D463-70.

  • Fan, T. W-M., Warmoes, M.O., Sun, Q., Song, H., Turchan-Cholewo, J., Martin, J.T., Mahan, A.L.,Higashi, R.M., Lane, A.N. (2016) Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator beta-glucan in a two-case ex vivo non-small cell lung cancer study. CSH Molecular Case Studies J. 2, a0008.

  • Li, J., Song, J., Zaytseva, Y.Y., Liu, Y., Rychahou, P., Jiang, K., Starr, M.E., Kim, J.T., Harris, J.W., Yiannikouris, F.B., Katz, W.S., Nilsson, P.M., Orho-Melander, M., Chen, J., Zhu, H., Fahrenholz, T., Higashi, R.M., Gao, T., Morris, A.J., Cassis, L.A., Fan, T. W-M., Weiss, H.L., Dobner, P.R., Melander, O., Jia, J., Evers, B.M. (2016) An obligatory role for neurotensin in high fat diet-induced obesity. Nature 533, 411–415
  • Lane, A.N., Higashi, R.M. & Fan, T. W-M. (2016) Models for evaluating drug responses in cancer by Stable Isotope Resolved Metabolomics (SIRM). Metabolomics 12, 108.
  • Beger, R.D., Dunn, W., Schmidt, M.A., Gross, S.S., Kirwan, J.A., Cascante, M., Brennan, L., Wishart, D.S., Oresic, M., Hankemeier, T., Broadhurst, D.I., Lane, A.N., Suhre, K., Kastenmüller, G., Zanetti, K., Kaddurah-Daouk, R. (2016) Metabolomics Enables Precision Medicine - “A White Paper, Community Perspective” Metabolomics, 12, 149
  • Wang,Q., Zhou,Y., Rychahou, P., Fan, T.W-M., Lane, A.N., Weiss, H.L., Evers, B.M. (2016) Ketogenesis contributes to intestinal cell differentiation. Cell Death and Disease, 24, 458-468
Others using the facilities:
  • Unruh, D. et al. (2016) Mutant IDH1 and thrombosis in gliomas. Acta Neuropathologica 132, 917-930

2015 (9)

  • Lane, A.N., Arumugam, S., Lorkiewicz P.K., Higashi, R.M., Laulhe, S., Nantz, M.H., Moseley, H.N.B., Fan, T. W-M. (2015) Chemoselective detection of carbonyl compounds in metabolite mixtures by NMR. Mag Res Chem. 53, 337-343 DOI 10.1002/mrc.4199
  • Sellers, K., Fox, M.P., Bousamra, M., Slone, S., Higashi, R.M.,Miller, D.M., Wang, Y., Yan, J., Yuneva, M., Deshpande, R., Lane, A.N.,Fan, T. W-M. (2015) Pyruvate Carboxylase is Critical in Non-Small Cell Lung Cancer. J. Clin. Invest. 125(2): 687-698 .doi:10.1172/JCI72873. [Commentary by C.T. Hensley, R.J. DeBerardinis J Clin Invest. 2015;125(2):495-497]
  • Lane, A.N. & Fan, T. W-M. (2015) Regulation of mammalian metabolism and biosynthesis. Nucl. Acids Res. 43, 2466-2485
  • Yao S, Flight RM, Rouchka EC, Moseley HNB. (2015) Proteins 83, 1470-87 A less-biased analysis of metalloproteins reveals novel zinc coordination geometries. Proteins 83, 1470-87
  • Tarrado-Castellarnaua, M., Zanuy, R.C.M., Tarragó-Celada, J., Polat, I.H., Hill, R., Fan, T. W-M., Link, W. Marta Cascante, M. (2015) Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition. Pharmacological Research. 102:218-234
  • Nalabothula N, Al-Jumaily T, Eteleeb AM, Flight RM, Xiaorong S, Moseley H Nalabothula N, Al-Jumaily T, Eteleeb AM, Flight RM, Xiaorong S, Moseley H, Rouchka EC, Fondufe-Mittendorf YN. Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation PLoS One. 10:e0135410
  • Saxena, N., Maio, N., Crooks, D.R., Ricketts, C.J., Yang, Y., Wei, M-H., Fan, T. W-M., Lane, A.N., Sourbier, C., Rouault, T.A., Linehan, W.M. (2015) SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery JNCI 108, djv287
  • Liu M, Luo F, Ding C, Albeituni S, Hu X, Ma Y, Cai Y, McNally L, Sanders MA, Jain D, Kloecker G, Bousamra M 2nd, Zhang HG, Higashi RM, Lane AN, Fan TW, Yan J. (2015) Particulate β-Glucan Converts Immunosuppressive Macrophages into M1 Phenotype Through Dectin-1-induced Syk-Card9-Erk Pathway and Raf-1-c-Maf Pathway. J. Immunol. 195, 5055-5065
  • Lane, A.N., Fan, T. W-M., Yan, J. (2015) 13C Tracer studies in mouse tumor xenografts. Bio-protocol 5(22): e1650

2014 (10)

  • Higashi, R.M., Fan, T. W-M., Lorkiewicz, P.K., Moseley, H.N.B., Lane, A.N. (2014) Stable Isotope Labeled Tracers for Metabolic Pathway Elucidation by GC-MS and FT-MS. in Mass Spectrometry Methods in Metabolomics, vol. 1198 D. Raftery Editor, Humana Press. Ch. 11
  • Guin, S., Pollard, C., Owens, C., Ru, Y., Lew, C.R., Dancik, G., Spencer, A., Knight, S., HoGupta, S., Hansel, D., Hellerstein, M., Lorkiewicz, P.K., Lane, A.N., Fan, T. W-M., & Theodorescu, D.(2014) . AGL, a glycogen debranching enzyme lost in human glycogen storage disease, suppresses tumor growth. JNCI 106, dju062
  • Xie, H., Hanai,J., Ren, J-G., Kats, L., Burgess ,K., Bhargava, P.,Signoretti,S., Billiard, J., Duffy,K.J., Grant,A, Wang,X., Lorkiewicz, P.K., Schatzman,S., Bousamra II,M., Lane, A.N., Higashi, R.M., Fan, T. , W-M., Pandolfi,P.P.P., Sukhatme,V.P., and Seth, P. Targeting lactate dehydrogenase-A (LDH-A) inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor initiating cells. Cell Metabolism 19, 795–809
  • D.B. Wilburn, K.E. Bowen, K.A. Doty, S. Arumugam, A.N. Lane, P.W. Feldhoff, and R.C. Feldhoff (2014) Sexual selection drives a novel disulfide bond pattern in a three-finger protein pheromone. PLosOne. I 9(5):e96975
  • SS Gori, P Lorkiewicz, DS Ehringer, AC Belshoff, RM Higashi, TW-M Fan and MH Nantz (2014) Profiling Thiol Metabolites and Quantification of Cellular Glutathione using FT-ICR-MS Spectrometry. Analytical & Bioanalytical Chemistry 406, 4371-9
  • J-G. Ren, P. Seth, C. B. Clish, P. K. Lorkiewicz. R. M. Higashi, A. N. Lane, T.W.-M. Fan and V. P. Sukhatme. (2014) Knockdown of Malic Enzyme 2 Suppresses Lung Tumor Growth. Scient. Reports 4, 5414
  • Mitchell, J.M., Fan, T. W-M., Lane, A.N., Moseley, H.N.B. (2014) Informatics approaches to ‘omics systems integration Frontiers in Genetics (Systems Biology) 5, 237
  • Chesney, J., Clark, J., Klarer, A.C.,Imbert-Fernandez, Y., Lane, A.N. and Telang, S. (2014) Fructose-2,6-Bisphosphate Synthesis by PFKFB4 is Required for the Glycolytic Response to Hypoxia and Tumor Growth. Oncotarget 5, 6670-6686
  • Eteleeb, A.M., Moseley, H.N.B., and Rouchka, E.C. (2014) “A Comparison of Combined P-value Methods for Gene Differential Expression Using RNA-Seq Data” Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology and Health Informatics, pp 417-425
  • Pan J, Bhardwaj M, Faulkner JR, Nagabhyru P, Charlton ND, Higashi RM, Miller AF, Young CA, Grossman RB, Schardl CL. (2014) Ether bridge formation in loline alkaloid biosynthesis. Phytochemistry 98:60-8

2013 (9)

  • Fan, T.W-M., & Lane, A.N (2013) Methodologies for Metabolomics: Experimental Strategies and Techniques, edited by Norbert Lutz, Jonathan V. Sweedler, and Ron A.Weavers Cambridge University Press. Ch 24. ISBN:9780521765909
  • Maldonado, C., Pushpakumar, S.B., Arumugam, S., Perez-Abadio, G., Lane, A.N. (2012) Administration of Exogenous ATP to Ischemic Skeletal Muscle Induces an Energy Sparing Effect that Involves Adenosine Receptors. Journal of Surgical Research 181:e15-22. DOI: 10.1016/j.jss.2012.06.033
  • Lane A.N. (2013) Bacterial repression: The Lac and Trp Systems. Online Encyclopedia of Biophysics, Springer Verlag. Pp 168-172DOI 10.1007/978-3-642-16712-6
  • Reynolds, M.R., Lane, A.N., Kemp, S., Liu, Y., Hill, B., Dean, D.C., Clem, B.F. (2013) Control of Glutamine Metabolism By the Tumor Suppressor Rb. Oncogene 33(5):556-66
  • Dong, C., Yuan, T., Wu, Y., Wang, Y., Fan, T. W-M., Miriyala, S., Lin, Y., Yao, J., Shi, J., Lorkiewicz, P.K., St Clair, D., Hung, M-C., Evers, B.M., and Zhou, B.P. (2013) Loss of FBP1 by Snail-mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer. Cancer Cell 23, 316-331
  • Moseley, H.N.B. (2013) Error Analysis and Propagation in Metabolomics Data Analysis. Computational and Structural Biotechnology Journal. 4, e201301006
  • Buscaglia, R., Miller, M; Dean, W.L.; Gray, R.D.; Lane, A.N.; Trent, J.O.; Chaires, J.B. (2013) Polyethylene glycol binding alters G-quadruplex structure by conformational selection. Nucl. Acids Res., 41:7934-46.
  • Yang, Y., Lane, A.N., Fan, T.W-M., Rickets, C., Wu, M., Boros, L., Linehan, W.M. Understanding How Fumarate Hydratase (FH) Null Cells Use its Central Carbon for Energy and Malignant Development . PlosOne 8, e72179
  • Carreer, W.J., Flight, R.M., Moseley, H.N.B. (2013) “A computational framework for high-throughput isotopic natural abundance correction of omics-level ultra-high resolution FT-MS datasets” Metabolites, 3, 853-866.

2012 (15)

  • Yuneva, M.O., Fan, T.W-M., Higashi, R.M., Allen, T.A., Balakrishnan, A., Goga, A., Ferraris, D.V., Tsukamoto, T., Wang, C., Seo, Y., Xin Chen, X., Bishop, J.M. (2012) The Initiating Oncogenic Lesion Determines Metabolic Properties of Tumors and Cellular Sensitivity to Inhibition of Glutaminase. Cell Metabolism 15:157-70
  • Fan, T. W-M., Lorkiewicz, P., Sellers, K., Moseley, H.N.B., Higashi, R.M., Lane, A.N. (2012) Stable Isotope-resolved metabolomics: past, present, and future. Pharmacology & Therapeutics 133:366-91.
  • Lorkiewicz, P., Higashi, R.M., Lane, A.N., Fan, T. W-M. (2012) Method for nucleotide detection using direct-infusion FT-ICR MS for the purpose of Stable Isotopic Resolved Metabolomics (SIRM) analysis. Metabolomics. 8, 930-939. doi:10.1007/s11306-011-0388-y
  • Le, A., Lane, A.N., Hamaker, M., Bose, S., Barbi, J., Tsukamoto, T., Rojas, C.J., Slusher, B.S., Zhang, H., Zimmerman. L.J., Liebler, D.C., Slebos, R.J.C., Lorkiewicz, P.K., Higashi, R.M., Fan, T.W-M., and Dang, C.V. (2012) Myc induction of hypoxic glutamine metabolism and a glucose-independent TCA cycle in human B lymphocytes. Cell Metabolism 15, 110-121
  • Li M, Biswas S, Nantz MH, Higashi RM, Fu XA (2012) Preconcentration and analysis of trace volatile carbonyl compounds. Anal Chem. 84:1288-93.
  • Muenyi, C.S., Pinhas, A.R., Fan, T. WM., Brock, G.N., Helm, C. W. and States, J.C. (2012) “Sodium arsenite ± hyperthermia sensitize p53 expressing human ovarian cancer cells to cisplatin by modulating platinum DNA damage responses”, Toxicological Sciences 127:139-49.
  • Fan, T.W-M., Higashi, R.M. & Lane, A.N. (2012) "Overview of Metabolomics" in The Handbook of Metabolomics Methods in Pharmacology and Toxicology, vol. 17 Humana Press, Ch. 1 DOI 10.1007/978-1-61779-618-0_4,
  • Fan, T.W-M. (2012) "Considerations of Sample Preparation for Metabolomics Investigation." The Handbook of Metabolomics Methods in Pharmacology and Toxicology, vol. 17 Humana Press Ch. 2. DOI 10.1007/978-1-61779-618-0_4.
  • Fan, T.W-M. (2012) "Metabolomics-Edited Transcriptomics Analysis (META)" The Handbook of Metabolomics Methods in Pharmacology and Toxicology, vol. 17 Humana Press, Ch. 14. DOI 10.1007/978-1-61779-618-0_4,
  • Higashi, R.M. (2012) Structural Mass Spectrometry for Metabolomics. “The Handbook of Metabolomics Methods in Pharmacology and Toxicology, vol. 17” Humana Press Ch 4. DOI 10.1007/978-1-61779-618-0_4
  • Lane, A.N. (2012) “NMR applications in metabolomics." The Handbook of Metabolomics Methods in Pharmacology and Toxicology, vol. 17 Humana Press Ch 6. DOI 10.1007/978-1-61779-618-0_4
  • Poulo, J.M., Elston, T., Lane, A.N., Macdonald, J.M. and Cascante, M. (2012) "Introduction to Metabolic Control Analysis (MCA)." The Handbook of Metabolomics Methods in Pharmacology and Toxicology, vol. 17 Humana Press Ch. 9. DOI 10.1007/978-1-61779-618-0_4,
  • Bousamra, M., Day, J., Fan, T. W-M., Kloecker, G, Lane, A.N., Miller, D.M. (2012) “Clinical aspects of metabolomics“ The Handbook of Metabolomics Methods in Pharmacology and Toxicology, vol. 17 Humana Press Ch 3. DOI 10.1007/978-1-61779-618-0_4,
  • Liu, W., Le, A., Fan, T. W-M., Lane, A.N., Dang, C.V., Phang, J.M. (2012) "The reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses to c-MYC." Proc. Natl. Acad. Sci. 109:8983-8988
  • Mattingly, S.J., Xu, T., Nantz, M.H., Higashi, R.M. & Fan, T. WM. (2012) “A carbonyl capture approach for profiling oxidized metabolites in cell extracts” Metabolomics. 8: 989–996DOI:10.1007/s11306-011-0395-z

2011 (10)

  • Fan, T. W-M., Lane, A.N., Higashi, R.M., Yan, J. (2011) Stable Isotope Resolved Metabolomics of Lung Cancer in a SCID Mouse Model. Metabolomics 7, 257-269
  • Lane, A.N., Fan, T. W-M, Bousamra II, M., Higashi, R.M., Yan, J., Miller, D.M. (2011) Clinical Applications of Stable Isotope-Resolved Metabolomics (SIRM) in Non-Small Cell Lung Cancer. Omics 15, 173-182 DOI: 10.1089/omi.2010.0088
  • Moseley, H.N.B., Higashi, R.M., Fan, T. W-M., Lane, A.N. (2011) Analysis of Non-Steady State Stable Isotope-Resolve Metabolism of UDP-GlcNAc and UDP-GalNAc. Proceedings of BIOINFORMATICS 2011– Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms. (Ed. Marco Pellegrini, Ana Fred, Joaquim Filipe, and Hugo Gamboa). SciTePress, Portugal, pp 108-115
  • Fan, T.W-M. & Lane, A.N. (2011) NMR-based Stable Isotope Resolved Metabolomics in Systems Biochemistry. J. Biomolec. NMR Sp. Edn. 49, 267–280
  • Moseley, H.N.B., Lane, A.N., Belshoff, A.C, Higashi, R.M. Fan, T. W-M., (2011) Non-Steady State Modeling of UDP-GlcNAc Biosynthesis is Enabled by Stable Isotope Resolved Metabolomics (SIRM). BMC Biology 9, 37.
  • Fan, T. W-M.,Tan, J., McKinney, M.M. and Lane, A.N. (2011) Stable Isotope Resolved Metabolomics Analysis of Ribonucleotide and RNA Metabolism in Human Lung Cancer Cells. Metabolomics. 8, 517-527 DOI: 10.1007/s11306-011-0337-9
  • Lane, A.N. (2011) The stability of intramolecular DNA quadruplexes compared with other macromolecules. Biochimie. 94:277-86
  • Gracey AY, Lee TH, Higashi RM, Fan T. (2011) Hypoxia-induced mobilization of stored triglycerides in the euryoxic goby Gillichthys mirabilis. J Exp Biol. 15, 3005-12.
  • Muenyi CS, States VA, Masters JH, Fan TW-M, Helm CW, States JC. (2011) Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC). J Ovarian Res. 4:9.
  • Fu, X., Li, M., Biswas, S., Nantz, M.H., Higashi, R.M. (2011) A novel microreactor approach for analysis of ketones and aldehydes in breath Analyst. 136, 4662-4666

2010 (9)

  • A Yalcin, B Clem, S Makoni, A Clem, K Nelson, J Thornburg, D Siow, A N Lane, S E Brock, U Goswami, Eaton, J.W., Telang, S. & Chesney, J. (2010) "Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K /AKT signaling." Oncogene 29, 139–149 doi:10.1038/onc.2009.317
  • Fan, T. W-M. Yuan, P., Lane, A.N., Higashi, R.M., Wang, Y., Hamidi, A., Zhou, R., Xavier Guitart-Navarro, X., Chen, G., Manji, H.K., Kaddurah-Daouk, R. (2010) "Stable Isotope Resolved Metabolomic Analysis of Lithium Effects on Glial-Neuronal Interactions." Metabolomics 6, 165 - 179. DOI 10.1007/s11306-010-0208-9
  • Dailey, M.M., Miller, M.C., Bates, P.J., Lane, A.N., Trent, J.O. (2010) Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence. Nucl. Acids Res. 38, 4877-4888 (Featured article).
  • Moseley, H.N.B. (2010) Correcting for the effects of natural abundance in stable isotope resolved metabolomics experiments involving ultra-high resolution mass spectrometry. BMC Bioinformatics 11, 139
  • Selivanov, V. A., Vizan, P., Mollinedo, F., Fan, T. W-M., Lee, P. W. N., Cascante, M. (2010) Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis. BMC System Biol. Art 135
  • Fan, T. W-M. (2010) Metabolomics-Edited Transcriptomics Analysis (Meta) Comprehensive Toxicology vol. 2 (McQueen, C.A., ed) pp 685–706. Academic Press
  • Doblin, M., Fan, T. W-M., Foster, S., Garrett, R., Maher, W., Möller, G., Oram, L. L., Roach, A., and Wallschläger, D. (2010) “Sources, Speciation, and Environmental Partitioning”, in: Chapman PM, Adams WJ, Brooks ML, Delos CG, Luoma SN, Maher WA, Ohlendorf HM, Presser TS, Shaw DP (eds). Ecological Assessment of Selenium in the Aquatic Environment. SETAC Press, Pensacola, FL, USA.
  • Arumugam, S., Miller, M.C., Maliekal, J., Trent, J.O., and Lane, A.N. (2010) NMR Structure Note: Solution structure of the RBD1,2 domains from human nucleolin. J. Biomolec. NMR 47, 79-83. DOI: 10.1007/s10858-010-9412-1
  • Miller, M.C., Buscaglia, R., Chaires, J.B., Lane, A.N., Trent, J.O. (2010) Hydration determines the G-quadruplex stability and conformation of the human telomere 3’ sequence d(A(GGGTTA)3GGG)). JACS. 132, 17105-17107. DOI: 10.1021/ja105259m

2009 (7)

  • Lane, A.N., Fan, T. W-M. & Higashi, R.M. (2009) Metabolic acidosis and the importance of balanced equations. Metabolomics. 5, 163-165 DOI: 10.1007/s11306-008-0142-2
  • Fan, T. W-M., Bird, J.A,, Brodie, E.L., Lane, A.N. (2009) 13C-Isotopomer-based Metabolomics of Microbial Groups Isolated from Two Forest Soils. Metabolomics. 5, 108-122 DOI:10.1007/s11306-008-0150-2
  • Fan, T. W-M; Lane, A. N.; Higashi . M.; Bousamra II, M.; Kloecker, G.;. Miller, D. M. (2009) Erlotinib-sensitive and resistant lung tumors show radically different metabolic Profiles. Exp. Molec. Pathol. 87, 83-86 doi:10.1016/j.yexmp.2009.04.004
  • Fan, T.WM., Lane, A.N., Higashi, R.M., Farag, M.A., Gao, H., Bousamra, M. & Miller, D.M. (2009) Altered Regulation of Metabolic Pathways in Human Lung Cancer Discerned by 13C Stable Isotope-Resolved Metabolomics (SIRM). Molecular Cancer. 8:41 doi:10.1186/1476-4598-8-41
  • Lane, A.N., Fan, T. WM, Higashi, R.M., Tan, J., Bousamra, M. and Miller, D.M (2009) Prospects for clinical cancer metabolomics using stable isotope tracers. Exp. Molec. Pathol. 86, 165-173 Sp. Issue. doi:10.1016/j.yexmp.2009.01.005
  • Yalcin, A., Clem, B.F., Simmons, S., Lane, A.N, Nelson, K.K., Clem, A.L., Brock, E., Siow, D., Wattenberg, B., Telang, S. & Chesney, J. (2009) Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases. J. Biol. Chem. 284: 24223 - 24232.doi:10.1074/jbc.M109.016816
  • Lane, A.N., Fan, T. W-M., Xie, X. Moseley, H.N. & Higashi, R.M. (2009) Stable isotope analysis of lipid biosynthesis by high resolution mass spectrometry and NMR. Anal. Chim. Acta. 651, 201-208. doi:10.1016/j.aca2009.08.032

2008 (8)

  • McNeely, S. C., Belshoff, A. C.. Taylor, B. F.. Fan, T. W. M., McCabe, M. J., Pinhas, A.R., States, J. C. (2008) Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest. Toxicology and Applied Pharmacology 229, 252-261
  • Clem, B.F., Telang, S., Clem, A., Yalcin, A., Meier, J., Simmons, A., Rasku, M..A, Arumugam, S., Dean, W.L., Eaton, J., Lane, A.N., Trent, J.O. and Chesney. J.A. (2008) “Small Molecule Inhibition of 6-Phosphofructo-2-Kinase Activity Suppresses Glycolytic Flux and Tumor Growth” Molecular Cancer Therapeutics. 7, 110-120
  • Lane, A.N., Fan, T-WM. & Higashi, R.M. (2008) “Isotopomer-based metabolomic analysis by NMR and mass spectrometry". Methods in Cell Biology, Vol 84. Biophysical Tools for Biologists, Volume 1, edited by Drs. John J. Correia and H. William Detrich. Elsevier Science & Technology Books Ch. 18. pp 541-588. ISBN:9780123725202
  • Fan, T.W-M. & Lane, A.N. (2008) Structure-based profiling of Metabolites and Isotopomers by NMR, Prog. NMR Spectrosc. 52, 69-117 doi:10.1016/j.pnmrs.2007.03.002 (invited review)
  • Lane, A.N., Fan. T. W-M. and Higashi, R.M. (2008) “Stable isotope assisted metabolomics in cancer research”. IUBMB Life. 60, 124-129 DOI:10.1002/iub.00017 (Invited review)
  • Fan, T. W-M., Kucia M., Jankowski, K., Higashi, R.M., Rataczjak, M.Z., Rataczjak, J., & Lane, A.N. (2008) "Proliferating Rhabdomyosarcoma cells shows an energy producing anabolic metabolic phenotype compared with Primary Myocytes" Molecular Cancer 7:79

  • Thornburg, J.M., Nelson, K.K., Lane, A.N., Arumugam, S., Simmons, A. Eaton, J.W., Telang, S., & Chesney, J. (2008) Targeting Aspartate Aminotransferase in Breast Cancer Breast Cancer Res. 10:R84
  • Lane, A.N., Fan, T. W-M., Higashi, R.M., Deleeuw, L., and Yang, T.H. (2008) Stable isotope tracing in metabolic pathways in Modelling Complex Biological Systems In The Context Of The Genome (Patrick Amar, Francois Kepes, Vic Norris, Bernard Vandenbunder, Eds.). Pp 69-78

2007 (6)

  • Lane, A.N. & Fan, T. W-M. (2007) Determination of positional isotopomers in metabolites. Metabolomics 3, 79-86
  • Podrabsky JE , Lopez JP, Fan TW-M, Higashi R, Somero GN (2007) Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis J. Exp. Biol. 210, 2253-2266
  • Sansone S, Nikolau B, van Ommen B, Kristal B, Taylor C, Robertson D, Lindon J, Griffin J, Sumner L, van der Werf M, Hardy N, Morrison N, Mendes P, Kaddurah-Daouk R, Goodacre R, Fan TW-M, Fiehn O. (2007) The Metabolomics Standards Initiative (MSI). Nature Biotech 25:844-8
  • Sumner, L.W., Amberg, A., Barrett, D., Beger, R., Beale, M.H., Daykin, C. Fan, T. W-M., Fiehn, O., Goodacre, R., Griffin, J.L., Hardy, N., Higashi, R.M., Kopka, J., Lindon, J.C., Lane, A.N., Marriott, P., Nicholls, A.W., Reily, M.D., Viant, M. (2007) Proposed Minimum Reporting Standards for Chemical Analysis. Metabolomics. 3, 211-221
  • Kurtoglu, M., Gao, N., Maher, J.C., Lehrman, M.A., Wangpaichitr, M.,Savaraj, N., Lane, A.N. and Lampidis, T.J. . (2007) Under normoxia 2-deoxy-D-Glucose, but not 2-fluoro-deoxy-D-glucose, kills select tumor cells by interfering with N-linked glycosylation. Molecular Cancer Therapeutics 6: 3049-3058.
  • Telang, S., Lane, A.N., Nelson, K.K. Arumugam, S. & Chesney, J.A. (2007) The oncoprotein H-RasV12 increases mitochondrial metabolism Molec. Cancer. 6, 77 doi:10.1186/1476-4598-6-77

2005-2006 (3)

  • Fan, T. W-M., Bandura, L.L., Lane, A.N. & Higashi, R.M. (2005) Metabolomics-Edited Transcriptomics Analysis of Se Anticancer Action in human lung cancer cells. Metabolomics 1, 325-339.
  • Telang S. Yalcin A., Clem A. L.,Bucala R., Lane A. N., Eaton, J. W., & Chesney J. A. (2006) Ras Transformation Requires Metabolic Control by 6-Phosphofructo-2-Kinase. Oncogene 25: 7225-7234.
  • Fan, T. W-M., Bandura, L.L., Lane, A.N. & Higashi, R.M. (2006) “ Integrating Genomics and Metabolomics for Probing Se Anticancer Mechanisms” Drug Metabolism Reviews 38, 1-25
Topic revision: r151 - 21 Oct 2018, AndrewLane
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